![]() ![]() View abstract.Īhmad, A., Kong, D., Sarkar, S. Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis. View abstract.Īcharya, A., Das, I., Singh, S., and Saha, T. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Some of these medications that are changed by the liver include clozapine ( Clozaril), cyclobenzaprine ( Flexeril), fluvoxamine ( Luvox), haloperidol ( Haldol), imipramine ( Tofranil), mexiletine ( Mexitil), olanzapine ( Zyprexa), pentazocine (Talwin), propranolol ( Inderal), tacrine ( Cognex), theophylline, zileuton ( Zyflo), zolmitriptan ( Zomig), and others.Ībdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., and Safe, S. Before taking diindolylmethane, talk to your healthcare provider if you take any medications that are changed by the liver. Taking diindolylmethane along with some medications that are changed by the liver can decrease the effectiveness of some medications. Diindolylmethane might increase how quickly the liver breaks down some medications. Some medications are changed and broken down by the liver. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. Some "water pills" that can decrease sodium include acetazolamide (Diamox), chlorothiazide ( Diuril), chlorthalidone ( Thalitone), furosemide ( Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. Taking sodium-depleting "water pills" along with diindolylmethane might decrease sodium too much. Some "water pills" can also decrease the amount of sodium in the body. Water pills (Diuretic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.ĭiindolylmethane might reduce the amount of sodium in the body. Taking large amounts of diindolylmethane might interfere with hormone replacement therapy. Other effects of diindolylmethane might oppose the effects of estrogen. Some of the effects of diindolylmethane might be similar to the hormone estrogen. Until more is known, don't use diindolylmethane if you have a hormone-sensitive condition.ĮstrogensInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider. However, developing research also suggests that diindolylmethane might work against estrogen and could possibly be protective against hormone-dependent cancers. These conditions include breast, uterine, and ovarian cancer endometriosis and uterine fibroids. Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Diindolylmethane might act like estrogen, so there is some concern that it might make hormone-sensitive conditions worse. Not enough is known about the safety of larger amounts of diindolylmethane when given to children. Not enough is known about the safety of larger amounts during pregnancy and breast-feeding.Ĭhildren: Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. Special Precautions & Warnings: Pregnancy and breast-feeding: Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. Taking 600 mg of diindolylmethane daily has been reported to lower sodium levels in some people. Taking larger doses of diindolylmethane is POSSIBLY UNSAFE. It is POSSIBLY SAFE for most people when taken by mouth short-term for medicinal purposes. A typical diet supplies 2-24 mg of diindolylmethane. ![]() Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).ĭiindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods. More evidence is needed to rate the effectiveness of diindolylmethane for these uses. Preventing prostate enlargement (benign prostatic hypertrophy, BPH).PSA levels can be used to measure the progress of prostate cancer. Early research suggest that taking a specific diindolylmethane product (BioResponse-DIM) for 28 days lowers prostate-specific antigen (PSA) levels in men with prostate cancer. Early research suggests that taking a specific diindolylmethane product (BioResponse-DIM by BioResponse) for 12 weeks does not improve markers of disease in women with cervical dysplasia. Abnormal growth of cells of the cervix (cervical dysplasia).Uses & Effectiveness Insufficient Evidence to Rate Effectiveness for. ![]()
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